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Arthritis Rheumatol 2017 02;69 (2): 343-351. 全文索取
Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians.

Abstract
A major barrier to genetic studies of osteoarthritis (OA) is the need to obtain large numbers of individuals with standardized radiographic evaluations for OA. To address this gap, we performed a genome-wide association study (GWAS) of radiographically defined tibiofemoral knee OA in 3,898 cases and 3,168 controls from 4 well-characterized North American cohorts, and we performed replication analysis of previously reported OA loci. These findings provide suggestive evidence of a novel knee OA locus and confirm previously reported associations in GDF5, CHST11, and FTO.

PMID: 27696742 [Pubmed - MEDLINE]

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