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Curr Genomics 2017 Jun;18 (3): 287-297. 全文索取
Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome.

Abstract
Relatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers. Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, in-cluding a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001). Roles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein struc-tures.

PMID: 28659724 [Pubmed - PubMed-not-MEDLINE]

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